Silica final lenses under HiPER laser fusion reactor operation conditions

We have studied the thermo-mechanical response and atomistic degradation of final lenses in HiPER project. Final silica lenses are squares of 75 × 75 cm2 with a thickness of 5 cm. There are two scenarios where lenses are located at 8 m from the centre: •HiPER 4a, bunches of 100 shots (maximum 5 DT shots <48 MJ at ≈0.1 Hz). No blanket in chamber geometry. •HiPER 4b, continuous mode with shots ≈50 MJ at 10 Hz to generate 0.5 GW. Liquid metal blanket in chamber design

An overview on armor research for the laser fusion project HiPER

During the current preparatory phase of the European laser fusion project HiPER, an intensive effort has being placed to identify an armour material able to protect the internal walls of the chamber against the high thermal loads and high fluxes of x-rays and ions produced during the fusion explosions. This poster addresses the different threats and limitations of a poly-crystalline Tungsten armour. The analysis is carried out under the conditions of an experimental chamber hypothetically constructed to demonstrate laser fusion in a repetitive mode, subjected to a few thousand 48MJ shock ignition shots during its entire lifetime. If compared to the literature, an extrapolation of the thermomechanical and atomistic effects obtained from the simulations of the experimental chamber to the conditions of a Demo reactor (working 24/7 at hundreds of MW) or a future power plant (producing GW) suggests that “standard” tungsten will not be a suitable armour. Thus, new materials based on nano-structured W and C are being investigated as possible candidates. The research programme launched by the HiPER material team is introduced

Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival

Background and objective: T-cell acute lymphoblastic leukemia (T-ALL) in children representsa high-risk disease. There is a lack of studies assessing the outcome of T-ALL in Hispanicpopulations, in which it is a rare malignancy. We report the characteristics and results oftreatment for childhood T-cell ALL in children over 14 years at a Latin American referencecenter.Material and methods: From January 2005 to December 2018, there occurred the analysisof twenty patients ≤ 16 years of age from a low-income open population diagnosed ata university hospital in Northeast Mexico. Clinical and laboratory characteristics, treat-ment regimens and outcomes were assessed by scrutinizing clinical records and electronicdatabases. Diagnosis was confirmed by flow cytometry, including positivity for CD-2, 5, 7and surface/cytoplasmic CD3. Survival rates were assessed by the Kaplan-Meier method.Results: There was a male preponderance (70 %), with a 2.3 male-to-female ratio (p = .074), themedian age being 9.5 years. Leucocytes at diagnosis were ≥ 50 × 109/L in 13 (65 %) children,with CNS infiltration in 6 (30 %) and organomegaly in 10 (50 %). The five-year overall survival(OS) was 44.3 % (95 % CI 41.96–46.62), significantly lower in girls, at 20.8 % (95 % CI 17.32–24.51)vs. 53.1 % (95 % CI 50.30–55.82), (p = .035) in boys; there was no sex difference in the event-freesurvival (EFS) (p = .215). The survival was significantly higher after 2010 (p = .034).Conclusion: The T-cell ALL was more frequent in boys, had a higher mortality in girls and thesurvival has increased over the last decade with improved chemotherapy and supportivecare

Lecturas

Manuel Alberga. La escritura invisible: Testimonios sobre el diario íntimo (Por Ananda de Carlos: Una mirada sobre lo invisible).-- Atilio Bartoli Langeli. La scrittura dell'italiano (Por Antonio Castillo Gómez: El derecho a escribir o la conquista de un privilegio).-- Antonio Castillo Gómez. Escrituras y escribientes (Por José Manuel Lucía Megías: Anotaciones marginales a la Cultura escrita).-- Rita Marquilhas. A Faculdade das Letras. Leitura e escrita em Portugal no séc. XVII (Por Antonio Castillo Gómez: Cultura escrita y alfabetización en el Portugal del siglo XVII).-- Armando Petrucci. Alfabetismo, cultura, sociedad (Por Vanessa de Cruz: La huella fundacional de un maestro del estudio de la Cultura escrita).-- Jesús D. Rodríguez Velasco. El debate sobre la caballería en el siglo XV: La tratadística caballeresca castellana en su marco europeo (Por David García Hernán: El marco institucional y político de los caballeros en el s. XV)Publicad

Adiponectin gene variant rs3774261, effects on lipid profile and adiponectin levels after a high polyunsaturated fat hypocaloric diet with Mediterranean pattern

Producción CientíficaThe role of ADIPOQ gene variants on metabolic improvements after weight change secondary to different hypocaloric diets remained unclear. We evaluate the effect of rs3774261 of ADIPOQ gene polymorphism on biochemical improvements and weight change after high polyunsaturated fat hypocaloric diet with a Mediterranean dietary pattern for 12 weeks. A population of 361 obese subjects was enrolled in an intervention trial with a calorie restriction of 500 calories over the usual intake and 45.7% of carbohydrates, 34.4% of fats, and 19.9% of proteins. The percentages of different fats was; 21.8% of monounsaturated fats, 55.5% of saturated fats, and 22.7% of polyunsaturated fats. Before and after intervention, an anthropometric study, an evaluation of nutritional intake and a biochemical evaluation were realized. All patients lost weight regardless of genotype and diet used. After 12 weeks with a similar improvement in weight loss (AA vs. AG vs. GG); total cholesterol (delta: −28.1 ± 2.1 mg/dL vs. −14.2 ± 4.1 mg/dL vs. −11.0 ± 3.9 mg/dL; p = 0.02), LDL cholesterol (delta: −17.1 ± 2.1 mg/dL vs. −6.1 ± 1.9 mg/dL vs. −6.0 ± 2.3 mg/dL; p = 0.01), triglyceride levels (delta: −35.0 ± 3.6 mg/dL vs. 10.1 ± 3.2 mg/dL vs. −9.7 ± 3.1 mg/dL; p = 0.02), C reactive protein (CRP) (delta: −2.3 ± 0.1 mg/dL vs. −0.2 ± 0.1 mg/dL vs. −0.2 ± 0.1 mg/dL; p = 0.02), serum adiponectin (delta: 11.6 ± 2.9 ng/dL vs. 2.1 ± 1.3 ng/dL vs. 3.3 ± 1.1 ng/dL; p = 0.02) and adiponectin/leptin ratio (delta: 1.5 ± 0.1 ng/dL vs. 0.3 ± 0.2 ng/dL vs. 0.4 ± 0.3 ng/dL; p = 0.03), improved only in AA group. AA genotype of ADIPOQ variant (rs3774261) is related with a significant increase in serum levels of adiponectin and ratio adiponectin/leptin and decrease on lipid profile and C-reactive protein (CRP)

Role of Beta2 adrenergic receptor polymorphism (rs1042714) on body weight and glucose metabolism response to a meal-replacement hypocaloric diet

Producción CientíficaThe Beta2-adrenergic receptor (ADRB2) is involved in energy balance regulation. The objective of our study was to evaluate the role of rs1042714 genetic variant of ADRB2 gene on weight loss, body composition and metabolic changes secondary to partial Meal replacement (pMR) hypocaloric diet in women with obesity. G allele of rs rs1042714 predicts the magnitude of weight loss resulting from a pMR diet. These adiposity improvements produce a better improvement of insulin resistance and percentage of impaired glucose metabolism in G allele carriers

The Role of the Spatial and Temporal Radiation Deposition in Inertial Fusion Chambers: The case of HiPER

The first wall armour for the reactor chamber of HiPER will have to face short energy pulses of 5 to 20 MJ mostly in the form of x-rays and charged particles at a repetition rate of 5–10 Hz. Armour material and chamber dimensions have to be chosen to avoid/minimize damage to the chamber, ensuring the proper functioning of the facility during its planned lifetime. The maximum energy fluence that the armour can withstand without risk of failure, is determined by temporal and spatial deposition of the radiation energy inside the material. In this paper, simulations on the thermal effect of the radiation–armour interaction are carried out with an increasing definition of the temporal and spatial deposition of energy to prove their influence on the final results. These calculations will lead us to present the first values of the thermo-mechanical behaviour of the tungsten armour designed for the HiPER project under a shock ignition target of 48 MJ. The results will show that only the crossing of the plasticity limit in the first few micrometres might be a threat after thousands of shots for the survivability of the armour

The mRNA degradation factor Xrn1 regulates transcription elongation in parallel to Ccr4

Co-transcriptional imprinting of mRNA by Rpb4 and Rpb7 subunits of RNA polymerase II (RNAPII) and by the Ccr4–Not complex conditions its posttranscriptional fate. In turn, mRNA degradation factors like Xrn1 are able to influence RNAPII-dependent transcription, making a feedback loop that contributes to mRNA homeostasis. In this work, we have used repressible yeast GAL genes to perform accurate measurements of transcription and mRNA degradation in a set of mutants. This genetic analysis uncovered a link from mRNA decay to transcription elongation. We combined this experimental approach with computational multi-agent modelling and tested different possibilities of Xrn1 and Ccr4 action in gene transcription. This double strategy brought us to conclude that both Xrn1-decaysome and Ccr4–Not regulate RNAPII elongation, and that they do it in parallel. We validated this conclusion measuring TFIIS genome-wide recruitment to elongating RNAPII. We found that xrn1Δ and ccr4Δ exhibited very different patterns of TFIIS versus RNAPII occupancy, which confirmed their distinct role in controlling transcription elongation. We also found that the relative influence of Xrn1 and Ccr4 is different in the genes encoding ribosomal proteins as compared to the rest of the genome

TechnoFusion: new Spanish singular scientific-technical facility for fusion research

Technofusion is the scientific&technical installation for fusion research in Spain, based on three pillars: • It is an open facility to European users. • It is a facility with instrumentation not accesible to small research groups. • It is designed to be closely coordiated with the European Fusion Program. With a budget of 80-100 M€ over five years, several top laboratories will be constructe